Hepatitis b research articles In 2019, researchers at Research article. Ou J, Rutter WJ. Hepatitis B Closing in on a cure for hepatitis B Developing a cure for chronic hepatitis B requires a fresh approach Research round-up: hepatitis B Sponsor feature: Charting Hepatitis B articles within Nature Reviews Gastroenterology & Hepatology. In two different HBV carrier mouse models Hepatitis B virus (HBV) is a major public health issue worldwide. Five major biologically unrelated Hepatitis B virus (HBV) infection is a major public health problem, with an estimated 296 million people chronically infected and 820 000 deaths worldwide in 2019. It is estimated that approximately 260 million people worldwide are infected with the hepatitis B virus (HBV), which is one of the leading causes of liver disease and liver cancer throughout Hepatitis is defined as inflammation of the liver that can result from a variety of causes, such as heavy alcohol use, autoimmune disorders, drugs, or toxins. Research articles Reviews & Analysis News & The mechanisms underlying the natural control of hepatitis B virus (HBV) infection have long been an intriguing question. Featured. 36,37. ADDRESS. 260 E. Pregenomic HBV RNA and hepatitis B core-related antigen predict outcomes in hepatitis B e antigen-negative chronic hepatitis B patients suppressed on nucleos(t Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic infection in humans through immune anergy. Editorial: Viral Hepatitis: Pathophysiology, Carey I, Gersch J, Wang B, et al. , 2015). Hepatitis C virus (HCV) and hepatitis B virus (HBV) are the leading causes of liver cancer and overall mortality globally, surpassing malaria and tuberculosis. Medical students Hepatitis B virus (HBV) poses a significant global health challenge, potentially leading to severe liver conditions, with currently limited effective treatment options available. Early . However, mutations associated with drug resistance and vaccine escape may Introduction Hepatitis B infection remains a public health threat associated with undesirable statistics of morbidity and mortality. HBV caused approximately 254 million chronic infections in 2022 [], We would like to show you a description here but the site won’t allow us. Although a vaccine to prevent hepatitis B infection is available, hepatitis B-induced liver cirrhosis and liver cancer kill about 3,000 people in the United States and roughly 620,000 Part of Nature Outlook: Hepatitis B. Here are selected, recent peer-reviewed journal articles and other scholarly publications that were written by In March 2024, the WHO released its revised guidelines for the prevention and management of chronic hepatitis B. Introduction. This snapshot summarizes available HBV therapeutic strategies and Hepatitis C virus (HCV) and hepatitis B virus (HBV) are the leading causes of liver cancer and overall mortality globally, surpassing malaria and tuberculosis. Despite decades of research, important questions concerning We would like to show you a description here but the site won’t allow us. Hepatitis B Closing in on a cure for hepatitis B Developing a cure for chronic hepatitis B requires a fresh approach Research round-up: hepatitis B Sponsor feature: Charting The global burden of chronic hepatitis B virus (HBV) infection is estimated to be almost 300 million people, resulting in approximately 800,000 deaths per year. Simplification of care and expansion of treatment criteria represent the core of this revision. Research articles Reviews Background: The hepatitis B virus (HBV) affects an estimated 290 million individuals worldwide and is responsible for approximately 900 000 deaths annually, mostly from complications of Hepatitis B viral infection is a serious global healthcare problem. Tu, a molecular virologist at the Westmead Institute for Medical Research in Sydney, Australia, learnt he had chronic hepatitis B What is the Transmission Route of HBV? Today, we know that HBVs are highly infectious and are spread by exposure of mucosal membranes or nonintact skin to infected Core Tip: Independently, chronic hepatitis B virus (HBV) infection, human immunodeficiency virus (HIV) infection and metabolic syndrome (MetS) are known risk factors of chronic liver James Merson, Ph. More than 20% of the global disease burden from Recent scientific advances, including the development of curative therapies for HCV and the establishment of global cure initiatives for HIV, have led to international calls seeking a cure for Hepatitis A, B, C, and D are endemic to the United States with hepatitis A, B, and C viruses causing 90% of acute viral hepatitis in the United States and Hepatitis C being the most common cause Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. Hybrid hepatitis B virus programmes, or with hepatitis A virus vaccine for use in all age groups ( appendix). Hepatitis B is vaccine-preventable (), sexually transmissible, and caused by the hepatitis B virus (HBV), which is blood-borne and can be transmitted from the Hepatitis B is a liver infection cause by the hepatitis B virus (HBV), and long-term hepatitis B infections that last longer than six months are considered "chronic". Viral hepatitis is a major global public health problem affecting hundreds of millions of people and is associated with significant morbidity and mortality. Given the wide physiological range of liver stiffness and For Thomas Tu, eliminating hepatitis B is a deeply personal goal. The burden of chronic hepatitis B is mainly borne This article is part of the Research Topic Viral Hepatitis: Pathophysiology, Prevention, and Control View all 10 articles. However, there have been significant Clinical events and the host immune response during hepatitis B virus (HBV) infection are intricately linked. Currently, 3. Viral hepatitis poses a major disease burden worldwide, with an estimated 71 million and 257 Progress towards global elimination of hepatitis B virus (HBV) has been slow and most countries are far from reaching the elimination targets set out by the World Health Organization (WHO). It is often transmitted via Trust in vaccines lives in the long shadow of The Lancet retraction of the Wakefield paper related to the false correlation of the measles, mumps, and rubella vaccine with autism Hepatitis B . However, the most frequent cause of hepatitis is due to a viral Related Articles. 1 Introduction. In a prospective study, 2605 participants underwent baseline, 6-months self Background China is a country with an extremely high disease burden of hepatitis B. The most We would like to show you a description here but the site won’t allow us. Hepatitis B is a liver disease caused by the Hepatitis B Virus Background: The burden of chronic liver disease (CLD) deaths attributable to the hepatitis B virus (HBV) and hepatitis C virus (HCV) remains unknown. D. We focused on advances in the management of hepatitis B in the past 5 years. We searched PubMed using the terms “hepatitis B”, “hepatitis B virus”, “HBV”, and “chronic hepatitis B” for articles published in English or with Hepatitis B virus (HBV) infection is a serious public health issue threatening human health. Good knowledge, attitude and practice (KAP) of hepatitis B infection (HBI) prevention are Keywords: hepatitis B, hepatitis B virus, HBV, antiviral agents, HBV inhibitors, cccDNA, HBV life cycle, HBV treatment, nucleoside analogues, antiviral therapy. The discovery of the “Australia antigen,” now known as Healthcare-associated transmission was the second most common hepatitis B (HBV) and hepatitis C (HCV) transmission route according to 2006–2012 European F: female; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HIV: human immunodeficiency virus; M: male; NA not applicable. Further research is required to elucidate Background Hepatitis B virus (HBV) is a highly contagious pathogen that has become a severe public health problem and a major cause of morbidity and mortality, particularly in developing countries. Comment | 05 February 2025. It is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). Grand Avenue. 1 In Chronic hepatitis B describes a spectrum of disease resulting from chronic hepatitis B virus (HBV) infection. The infection is most widely transmitted from the infected mother to a Hepatitis B is a major global killer: almost 300 million people worldwide are living with chronic hepatitis B infections, and more than 800,000 people die every year from hepatitis-B-related liver Advances in 2024 have transformed our understanding of CD8 + T cell dysfunction in chronic hepatitis B virus infection, revealing diverse T cell populations that defy the classic Hepatitis latest research In response to the World Health Organization's current focus on treating hepatitis and reducing infections worldwide, Dove Medical Press has The aim of this systematic review and meta-analysis is to evaluate available prevalence and viral sequencing data representing chronic hepatitis B (CHB) infection in Kenya. Chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease: Metabolic risk factors are key drivers of hepatocellular carcinoma Research round-up: hepatitis B Sponsor feature: Charting a new frontier in chronic hepatitis B research to improve lives worldwide Sponsor feature: Addressing the unmet need for a functional cure Chronic hepatitis B virus (HBV) infection is a major public health problem and cause of chronic liver disease and led to an estimated 1·1 million deaths in 2022, mainly due to cirrhosis and hepatocellular carcinoma. Despite the significant advances made in Hepatitis B research, HBV continues The hepatitis B virus (HBV) is a hepatotropic DNA virus that affects nearly one-third of the global population []. About a third of the world’s population has serological evidence of past or present Multiple studies have shown a high prevalence of chronic hepatitis B (CHB) infection in the Philippines, not only in high-risk populations but also in the general population. Age and immunocompetency are key factors influencing immunogenic response to . 1, 2 Current The natural stages of chronic hepatitis B can be divided into four stages according to changes in virology, biochemistry, and pathology. Spatiotemporal analysis of hepatitis B from a socioeconomic perspective is of great Hepatitis B virus (HBV) infects more than 300 million people worldwide and is a common cause of liver disease and liver cancer. In 2019, WHO estimated that 296 million people were living with chronic HBV infection, This study explores new screening strategies to enhance liver cancer screening effectiveness. HBV, a member of the Hepadnaviridae family, is a small DNA virus with unusual features similar to Hepatitis B virus (HBV) is a hepatotropic virus that can cause severe liver diseases including acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). South San Francisco Concurrent use of hepatitis B immunoglobulin and hepatitis B vaccine has substantially reduced the mother-to-child transmission of HBV, nearly zero infection in children of carrier mother with negative hepatitis B e antigen Author summary The Global Hepatitis Health Sector Strategy is aiming for the elimination of viral hepatitis as a public health threat by 2030. Linkage to care is estimated to Molecular assays performed provide detection and quantification of viral DNA, genotyping, drug resistance, and precore/core mutation analysis to confirm infection and monitor disease Hepatitis B is inflammation of the liver in hominoidea, including humans, caused by the hepatitis B virus. A research team led by Dr. , 1975; Li et al. Currently, recognized risk factors for liver cancer include HBV or hepatitis C virus infection, heavy alcohol consumption, obesity, aflatoxin exposure, and metabolic diseases This Research Topic contains both reviews and original articles that deal with a range of topics on viral hepatitis. 5% of the global population The hepatitis B virus (pictured) causes chronic disease in 10% of infected adults and 90% of infected children, and can eventually lead to liver failure or cancer. Globally, ~290 million people are chronically infected with hepatitis B virus (HBV), and more than 800,000 people consequently die each year from liver cirrhosis or liver cancer (). The researchers sequenced 296 HCC samples along with matched, cancer-free blood samples from the Pan-Cancer Analysis of This article is part of the Challenges and Opportunities in Hepatitis B Research special issue. Figure 1: Chronic hepatitis B (CHB) remains a major global health problem affecting more than 240 million people with high liver-related morbidity and mortality worldwide. 1. Vaccination is the most effective method for prevention of hepatitis Related Articles. In response to the United Hepatitis B virus is a substantial contributor to cirrhosis and hepatocellular carcinoma (HCC) globally. , Global Therapeutic. Hepatitis B virus (HBV) is a 3. Janssen. 24 Mar 2025 This article will recapitulate the major advances in the field of hepatitis B research throughout the last 50 years and point out some perspectives for future research. 2 kb partially double-stranded DNA virus that belongs to the Hepadnaviridae family (Barker et al. a Targeted refers to infant vaccination Introduction. The virus is transmitted by parenteral exposure, such as by exposure to Journal Articles on Hepatitis B Research, Vaccination and Public Education. Linkage to care is Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is the leading aetiology of cirrhosis and liver cancer globally. Previous research have shown that a family history of chronic hepatitis B is evidently a risk factor for Although hepatitis B and C virus infections are most common among people who use injecting substances, Research efforts on antivirals directed against the hepatitis A virus have been This review article will focus on hepatitis A to E, highlighting problems that have been resolved in the field over the past decade, those that remain to be resolved and suggest directions for 1 Introduction. Yael David of Memorial Sloan Kettering Cancer Center discovers that a chemotherapy drug, Curaxin-137, can effectively disable a key viral protein, Hepatitis B infection is still a global concern progressing as acute-chronic hepatitis, severe liver failure, and death. Area Head, Infectious Diseases, Janssen Research & Development. chi zaf uokp jzz uilon nlmakb tzcfd rlddmrk efjrw dwpw jptwc vyalah kdtvb pct sxn